Health and Medicine

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Dr Joseph DeLozier | A Promising Treatment to Reduce Wrinkles and Sun Damage

Dr Joseph DeLozier | A Promising Treatment to Reduce Wrinkles and Sun Damage

Out of all patients diagnosed with breast cancer, only 1% are men. The classical presentation of male breast cancer consists of a painless and hard tumour that appears behind the areola – the circular area around the nipple. This is different from breast cancer in women, who can present a tumour in different parts of the breast. In some cases, however, male breast cancer can manifest at the same time as gynecomastia.

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Professor Dorothy Ibifuro Makanjuola | New Insights into Breast Cancer Presentation in Men

Professor Dorothy Ibifuro Makanjuola | New Insights into Breast Cancer Presentation in Men

Out of all patients diagnosed with breast cancer, only 1% are men. The classical presentation of male breast cancer consists of a painless and hard tumour that appears behind the areola – the circular area around the nipple. This is different from breast cancer in women, who can present a tumour in different parts of the breast. In some cases, however, male breast cancer can manifest at the same time as gynecomastia.

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Dr Zirui Huang | How the Brain’s Functional Geometry Could Encode Dimensions of the Mind

Dr Zirui Huang | How the Brain’s Functional Geometry Could Encode Dimensions of the Mind

The concept of consciousness extends beyond mere philosophical pondering. Scientists are currently exploring how conscious experience emerges from electrochemical processes within the brain. Unraveling this mystery holds significant implications for brain health, encompassing phenomena such as comas, surgical anesthesia, and the altered perceptions observed in schizophrenia. Emerging research indicates that consciousness is not localized to a single brain region, but rather arises as a result of network interactions. Understanding the intricate connections between brain regions that contribute to consciousness has remained a challenging endeavor.

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Professor Barrett Caldwell | Developing Effective Chronic Care for Patients with Traumatic Brain Injury

Professor Barrett Caldwell | Developing Effective Chronic Care for Patients with Traumatic Brain Injury

An estimated 69 million people worldwide are currently living with traumatic brain injury. Now recognised as a chronic condition, traumatic brain injury can lead to sleep disorders, depression, headaches and an increased risk of suicide. Unfortunately, the human factors involved in recovery remain understudied. Working to address this is Professor Barrett Caldwell, who leads the GROUPER Laboratory at Purdue University. He and his colleagues study the processes and technologies used to manage chronic conditions, to improve care systems for people living with traumatic brain injury.

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PrognostX Health | A New Test to Identify Chronic Kidney Disease – A Costly and Silent Killer

PrognostX Health | A New Test to Identify Chronic Kidney Disease – A Costly and Silent Killer

Chronic kidney disease is a common but irreversible condition that involves progressive loss of kidney function. In general, there are rarely any symptoms present as the disease progresses, and over 90% of individuals have no idea they even have it. Approximately 700 million people have chronic kidney disease worldwide and most are unaware of their irreversible condition. If the disease progresses to end-stage renal disease, patients require life-sustaining dialysis treatments three times per week, which negatively impacts on quality of life. While a kidney transplant can delay major issues, most who progress to end-stage will only live an additional 5 to 10 years.

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Dr Brian D. Tait | The Impact of Haplotyping on Disease Inheritance and Clinical Treatment

Dr Brian D. Tait | The Impact of Haplotyping on Disease Inheritance and Clinical Treatment

Humans inherit a version of each gene – an allele – from each parent. Through standard DNA analysis, it is not possible to know which allele of a given gene came from the mother and which came from the father. Understanding which allele came from which parent is known as ‘haplotyping’ or ‘genetic phasing’. This is particularly important when a gene has multiple changes in the gene sequence – called mutations.

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Dr Victor Serebruany | Investigating Misreporting in a Clinical Trial

Dr Victor Serebruany | Investigating Misreporting in a Clinical Trial

Clinical trials are the main way for scientists and doctors to test whether new treatments, such as drugs or devices, are safe and effective. Because of their pivotal importance in influencing treatment options and patient care, clinical trials must be conducted to the highest standards. For drugs, this means they are required to be proven safe and effective before they can gain government approval.

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Dr Julie Karand | Exploring Factors Linked to Arterial Stiffness in Tanzanian Adults

Dr Julie Karand | Exploring Factors Linked to Arterial Stiffness in Tanzanian Adults

The arteries carry oxygen-rich blood from the heart to all parts the body. Arterial stiffness, which describes the rigidity of the arteries’ walls, has been shown to increase the risk of developing cardiovascular disease. Cardiovascular disease is the leading cause of death across the globe. As such, investigating the factors linked to arterial stiffness is critical, as it could help doctors to identify those at high risk of developing cardiovascular disease.

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Professor William Richardson | What Mice in Mazes Can Teach Us About Working Memory

Professor William Richardson | What Mice in Mazes Can Teach Us About Working Memory

Our working memory can be described as a mental sticky note, where we hold bits of information for short periods of time. Working memory is an important function for everyday life, used for many tasks including following directions, holding conversations and solving problems of all kinds. Often, working memory – and problem-solving – can be improved by training.

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Professor Thomas Feuerstein | Using Mathematical Modelling to Understand Acute Heart Failure Treatment

Professor Thomas Feuerstein | Using Mathematical Modelling to Understand Acute Heart Failure Treatment

Cardiovascular diseases are the most common cause of death around the globe. Heart failure is a particular type of cardiovascular disease, which occurs when the heart is not able to pump blood around the body as well as it should. Over 26 million people in the world are currently affected by heart failure and this number is increasing every year.

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Dr Matthew Hoare | Understanding Gene Mutations in Chronic Liver Disease

Dr Matthew Hoare | Understanding Gene Mutations in Chronic Liver Disease

The liver plays a vital role in keeping us healthy, by controlling levels of sugars and fats in our blood, as well as clearing the blood of toxins. Chronic liver disease affects around 25% of the population and is reported to be the third largest cause of premature death in the UK. Liver disease can occur as the result of long-term consumption of alcohol or viral hepatitis, but the fastest growing cause is non-alcoholic fatty liver disease, associated with obesity and type 2 diabetes.

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