Dr. Wendi Quinn O’Neill | Repurposing an Anti-lipid Drug to Tackle HPV-Positive Head and Neck Cancer

Mar 12, 2025 | health and medicine

About this episode

HPV-positive head and neck cancer is driven by HPV – a virus that is well known to cause cervical cancer. HPV-positive head and neck cancer is typically treated with surgery, radiation, and/or chemotherapy. However, treatment outcomes are far from ideal, and there is a clear need for new therapies. This cancer features a viral protein called E6 as a lynchpin of its survival and growth. Previous research has shown that using genetic tools to block this protein can prevent tumor growth. E6, and the signaling pathways associated with it, may therefore represent a tantalizing therapeutic target for HPV-driven cancers. Read More

Original Article Reference

Summary of the paper ‘Repositioning Fenofibrate to Reactivate p53 and Reprogram the Tumor-Immune Microenvironment in HPV+ Head and Neck Squamous Cell Carcinoma’, in Cancers, doi.org/10.3390/cancers14020282

Contact

For further information, you can connect with Dr. Wendi Quinn O’Neill at wqo@case.edu

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