Dr Matthew Hoare | Understanding Gene Mutations in Chronic Liver Disease

Jun 28, 2023 | biology, health and medicine

About this episode

The liver plays a vital role in keeping us healthy, by controlling levels of sugars and fats in our blood, as well as clearing the blood of toxins. Chronic liver disease affects around 25% of the population and is reported to be the third largest cause of premature death in the UK. Liver disease can occur as the result of long-term consumption of alcohol or viral hepatitis, but the fastest growing cause is non-alcoholic fatty liver disease, associated with obesity and type 2 diabetes. Read More

Original Article Reference

Summary of the papers ‘Somatic mutations and clonal dynamics in healthy and cirrhotic human liver’, in Nature, https://doi.org/10.1038/s41586-019-1670-9; and ‘Convergent somatic mutations in metabolism genes in chronic liver disease’ in Nature, https://doi.org/10.1038/s41586-021-03974-6


For further information, you can connect with Dr Matthew Hoare at Matthew.Hoare@cruk.cam.ac.uk

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