Dr Mats Ljungman | KLIPP: Targeting Cancer with CRISPR

May 2, 2024 | biology, health and medicine

About this episode

Cancer treatments are designed to kill cells within a tumor, but they often affect healthy tissues, leading to serious side-effects. Thus, there is an urgent need to develop new approaches that specifically aim for targets that are unique for tumor cells. A common and early event in carcinogenesis is the formation of chromosomal structural variants. These rearrangements are unique for each tumor and contribute to the growth of the tumor. Structural variants in cancer cells create unique junctions of DNA sequences, which are typically located far apart in normal cells. Thus, these junctions represent a promising new target for precision cancer treatment. Read More


Summary of the paper ‘KLIPP – a precision CRISPR approach to target structural variant junctions in cancer’, doi.org/10.1101/2023.05.10.540176


For further information, you can connect with Dr. Mats Ljungman at ljungman@umich.edu

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