Dr Kerstin Kleinschmidt-Doerr | Could R399E Become a Potential Treatment for Restoring Joints and Relieving Pain in Osteoarthritis?

Feb 7, 2024 | health and medicine

About this episode

Osteoarthritis is a painful and debilitating condition that affects hundreds of millions of people. The condition significantly affects a patient’s mobility, sleep, and ability to work, ultimately impacting their quality of life and mental health. Treatments involve exercise or medication to reduce pain, but they don’t target underlying structural problems in the joints. Additionally, these treatments do not slow or stop the progression of the disease, and may have serious side-effects on organs such as the liver, kidneys or heart. The search for a treatment that can reduce osteoarthritis pain and treat the affected joint structures remains a ‘substantial unmet medical need’. Read More

Original Article Reference

Summary of the paper ‘R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis’, in Arthritis & Rheumatology, doi.org/10.1002/art.42343

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